Rhinovirus C and Respiratory Exacerbations in Children with Cystic Fibrosis
Author Information
Author(s): de Almeida Marina B., Zerbinati Rodrigo M., Tateno Adriana F., Oliveira Cristina M., Romão Renata M., Rodrigues Joaquim C., Pannuti Cláudio S., da Silva Filho Luiz Vicente F.
Primary Institution: Hospital das Clínicas da Faculdade de Medicina de Universidade de São Paulo
Hypothesis
To investigate a possible role for human rhinovirus C in respiratory exacerbations of children with cystic fibrosis.
Conclusion
A significant association was found between the presence of human rhinovirus C and respiratory exacerbations in children with cystic fibrosis.
Supporting Evidence
- At least 1 respiratory virus was identified in 49.8% of samples.
- Rhinovirus was the main identified agent in 34.1% of samples.
- Identification of rhinovirus subtypes A2 or C was significantly associated with respiratory exacerbations.
- Influenza A was associated with an increase in the risk for hospital admission.
Takeaway
This study found that a virus called rhinovirus C can make kids with cystic fibrosis sicker when they have breathing problems.
Methodology
Microbiologic testing on respiratory specimens from 103 patients was conducted, and virologic variables were analyzed using binomial generalized linear models.
Limitations
The findings cannot be extrapolated to infants with cystic fibrosis, who were underrepresented in the study.
Participant Demographics
49 girls and 54 boys, median age 8.9 years, age range 3.8 months to 17.8 years.
Statistical Information
P-Value
0.010
Confidence Interval
1.043–1.369
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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