Quercetin Suppresses COX-2 Expression and Angiogenesis
Author Information
Author(s): Xiao Xiangsheng, Shi Dingbo, Liu Liqun, Wang Jingshu, Xie Xiaoming, Kang Tiebang, Deng Wuguo
Primary Institution: State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China
Hypothesis
Quercetin inhibits COX-2 expression and COX-2-mediated angiogenesis through the inactivation of p300 signaling.
Conclusion
Quercetin effectively suppresses COX-2 expression and angiogenesis in breast cancer cells by targeting the p300 signaling pathway.
Supporting Evidence
- Quercetin significantly suppressed COX-2 mRNA and protein expression in breast cancer cells.
- Quercetin inhibited COX-2-mediated angiogenesis in human endothelial cells in a dose-dependent manner.
- Quercetin blocked the recruitment of the coactivator p300 to the COX-2 promoter.
Takeaway
Quercetin is a natural compound that can help stop cancer cells from growing by blocking a specific protein that helps those cells thrive.
Methodology
The study used Western blot, RT-PCR, and chromatin immunoprecipitation assays to analyze the effects of quercetin on COX-2 expression and activity.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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