Precipitation Polymerization-Based Molecularly Imprinted Polymers: A Novel Approach for Transdermal Curcumin Delivery
2024
New Method for Delivering Curcumin Through Skin
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Djunaidi Muhammad Cholid, Putri Viona Resda, Maharani Nesti Dwi, Lusiana Retno Ariadi, Siahaan Parsaoran, Sunarno Sunarno
Primary Institution: Diponegoro University
Hypothesis
Can molecularly imprinted polymers (MIPs) improve the transdermal delivery of curcumin?
Conclusion
The study found that MIPs can effectively control the release of curcumin, making them a promising option for transdermal delivery.
Supporting Evidence
- The MIP showed a maximum adsorption capacity of 4.239 mg/g, higher than the non-imprinted polymer (NIP) at 3.219 mg/g.
- The release of curcumin from the MIP was 41.26% after 8 hours, compared to 51.50% from the NIP.
- The MIP followed the Higuchi model for drug release kinetics, indicating controlled release.
Takeaway
Scientists created a special type of polymer that helps deliver curcumin through the skin better than regular methods.
Methodology
The MIP was synthesized using precipitation polymerization and characterized using SEM-EDX and FTIR spectroscopy.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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