Outbreaks of Novel Antigenic Variant Infectious Bursal Disease Virus in Japan (2014-2023)
Author Information
Author(s): Takahashi Mari, Oguro Shiori, Kato Atsushi, Ito Soma, Tsutsumi Nobuyuki
Primary Institution: Nippon Institute for Biological Science
Hypothesis
The study investigates the emergence and characteristics of novel antigenic variant strains of the infectious bursal disease virus (IBDV) in Japan.
Conclusion
The novel antigenic variant IBDV has spread in Japan, causing significant atrophy of the bursa of Fabricius in infected chickens.
Supporting Evidence
- Novel antigenic variant IBDVs were detected in 59.3% of samples in 2023.
- Atrophy of the bursa of Fabricius was observed in infected chickens.
- High copy numbers of the IBDV genome were found in lymphoid tissues.
Takeaway
Scientists found a new type of virus affecting chickens in Japan that makes them sick, even though they were vaccinated.
Methodology
The study involved RT-PCR testing of bursal samples from chickens and experimental infection of specific-pathogen-free chickens with the isolated virus.
Potential Biases
Potential bias due to the use of specific-pathogen-free chickens that may respond differently than commercial broilers.
Limitations
The study primarily focused on specific-pathogen-free chickens, which may not fully represent the field conditions in commercial poultry.
Participant Demographics
Broiler chickens aged 35 to 45 days were used for sample collection.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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