Diagnostic Value of Anti-CCP Antibodies in Greek Patients with Rheumatoid Arthritis
Author Information
Author(s): Alexiou Ioannis, Germenis Anastasios, Ziogas Athanasios, Theodoridou Katerina, Sakkas Lazaros I
Primary Institution: Thessaly University School of Medicine and Hospital
Hypothesis
The study assesses the diagnostic value of anti-CCP antibodies in Greek patients with rheumatoid arthritis.
Conclusion
Anti-CCP2 antibodies exhibit a better diagnostic value than RF and correlate with radiological joint damage in Greek patients with RA.
Supporting Evidence
- Anti-CCP antibodies had a sensitivity of 63.2% and specificity of 95.0% for RA.
- The presence of both anti-CCP antibodies and RF increased specificity to 98.2%.
- Anti-CCP antibodies were positive in 34.9% of RF-negative RA patients.
- There was a correlation between anti-CCP antibodies and radiographic joint damage.
Takeaway
Doctors can use a blood test for anti-CCP antibodies to help diagnose rheumatoid arthritis in Greek patients, especially when other tests are negative.
Methodology
The study used an ELISA kit to test anti-CCP antibodies in serum samples from patients with RA and compared results with rheumatoid factor.
Limitations
The study is cross-sectional and does not follow patients over time to assess long-term significance.
Participant Demographics
155 Greek patients with RA (76% women, mean age 60.3 years).
Statistical Information
P-Value
0.01
Confidence Interval
95% CI of 0.87 to 0.93
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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