ImmTree: A Database for Human Immune System Evolution
Author Information
Author(s): Csaba Ortutay, Markku Siermala, Mauno Vihinen
Primary Institution: University of Tampere
Hypothesis
A comprehensive database focused on the evolutionary relationships of immune-related genes will facilitate research in immunology and evolutionary biology.
Conclusion
ImmTree provides a unique data set of genes and proteins from the human immune system, their phylogenetics, and information for comparisons of human-mouse ortholog pairs.
Supporting Evidence
- ImmTree contains information about orthologs in 80 species.
- The database includes data for 847 human immune system related genes and proteins.
- Phylogenetic trees were reconstructed for ortholog groups using various methods.
- ImmTree allows complex queries for studying evolutionary relationships.
Takeaway
ImmTree is like a big library that helps scientists understand how our immune system has changed over time by showing how genes are related across different species.
Methodology
The database was constructed by collecting human immune system-related genes and proteins, analyzing their evolutionary relationships, and creating phylogenetic trees.
Limitations
The database does not include variable chains of immunoglobulins and focuses on genes that are conventionally structured.
Digital Object Identifier (DOI)
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