Experimental Diab. Res., 5:3-5, 2004
2004
The Role of C-Peptide in Diabetes and Insulin Function
publication
Evidence: moderate
Author Information
Author(s): Aaron Vinik
Primary Institution: Norfolk, Virginia
Hypothesis
Does C-peptide have a biological function beyond insulin processing?
Conclusion
C-peptide may play a significant role in various physiological functions and could be important for understanding diabetes.
Supporting Evidence
- C-peptide deficiency in type 1 diabetes is linked to reduced Na+/K+ ATPase activity.
- C-peptide administration can improve nerve function in type 1 diabetes.
- C-peptide may help restore blood flow and improve microvascular function in diabetes.
Takeaway
C-peptide is a part of insulin that might help with diabetes and other body functions, even though we didn't know it had a job before.
Limitations
The effects of C-peptide may not be clear in all diabetes models, particularly type 2 diabetes.
Digital Object Identifier (DOI)
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