Resistance to Cotrimoxazole and Rifampin in Brucella
Author Information
Author(s): Beig Masoumeh, Ebrahimi Elaheh, Moradkasani Safoura, Goodarzi Forough, Sholeh Mohammad, Golab Narges
Primary Institution: Pasteur Institute of Iran
Hypothesis
What is the prevalence of rifampin and cotrimoxazole resistance in Brucella species?
Conclusion
The study found a concerning rise in resistance to cotrimoxazole and rifampin in Brucella, particularly affecting pediatric cases.
Supporting Evidence
- The prevalence of cotrimoxazole resistance was found to be 0.034.
- The prevalence of rifampin resistance was found to be 0.046.
- Resistance trends showed significant increases over time, especially in B. melitensis.
- Subgroup analyses revealed variations in resistance based on geographical and temporal factors.
- High heterogeneity was observed in resistance patterns across studies.
Takeaway
Brucella bacteria are becoming resistant to important antibiotics, making it harder to treat infections, especially in children.
Methodology
The study conducted a systematic review and meta-analysis of 59 studies to assess resistance prevalence.
Potential Biases
Potential biases due to the retrospective nature of the studies included.
Limitations
The study included retrospective data and potential biases from the included studies.
Participant Demographics
Studies included data from 21 countries across various continents.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI, 0.017 to 0.068 for cotrimoxazole; 95% CI, 0.027 to 0.077 for rifampin
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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