Meropenem Levels in Peritoneal Dialysis Patients
Author Information
Author(s): Srithongkul Thatsaphan, Raksasuk Sukit, Techajongnumchai Bulaporn, Sritippayawan Suchai, Koomanachai Pornpan
Primary Institution: Siriraj Hospital, Mahidol University, Bangkok, Thailand
Hypothesis
Continuous intraperitoneal administration of meropenem will achieve adequate drug levels in patients with peritoneal-dialysis-related peritonitis.
Conclusion
A loading dose of 500 mg of intraperitoneal meropenem followed by 125 mg/L every 6 hours is effective in maintaining adequate drug levels for treating peritoneal dialysis-related peritonitis.
Supporting Evidence
- Four out of five patients responded positively to the treatment.
- The mean maximum dialysate meropenem level was 158.1 mg/L.
- Dialysate levels exceeded the minimal inhibitory concentration for resistant organisms throughout the study.
Takeaway
This study shows that giving a specific antibiotic directly into the belly can help treat infections in patients on dialysis.
Methodology
This was a prospective, descriptive study measuring plasma and dialysate meropenem levels in five patients with peritoneal dialysis-related peritonitis after administering a loading dose followed by continuous dosing.
Potential Biases
Potential bias due to the small sample size and lack of randomization.
Limitations
The study had a small sample size and included patients with varying types of infections, which may affect the generalizability of the results.
Participant Demographics
The mean age of participants was 59 years, with a mix of genders and varying causes of end-stage renal disease.
Digital Object Identifier (DOI)
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