Quality Control of Xuesaitong Injection Using Chemical Fingerprinting
Author Information
Author(s): Yao Hong, Shi Peiying, Shao Qing, Fan Xiaohui
Primary Institution: Pharmaceutical Informatics Institute, Zhejiang University, Hangzhou, China
Hypothesis
A simple and global quality evaluation method for the quality control of Xuesaitong injection can be developed.
Conclusion
Chemical fingerprinting and quantitative analysis identified most of the common saponins for the quality control of P. notoginseng products such as the XST injection.
Supporting Evidence
- 27 common saponins were identified and quantified using ten reference saponins.
- The developed analytical method was successfully applied to analysis of ten batches of the XST injection.
- All of the 27 characteristic peaks were determined simultaneously.
Takeaway
The study found a way to check the quality of a medicine made from a plant called Panax notoginseng by looking at its chemical fingerprints.
Methodology
High performance liquid chromatography-ultraviolet detection (HPLC-UV) was used to identify and quantify the chromatographic fingerprints of the XST injection.
Limitations
It was difficult to obtain reference compounds for all 27 saponins.
Digital Object Identifier (DOI)
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