E-cadherin as a prognostic indicator in primary breast cancer

Sample size: 174 publication Evidence: moderate

Author Information

Author(s): Parker C, Rampaul R S, Pinder S E, Bell J A, Wencyk P M, Blamey R W, Nicholson R I, Robertson J F R

Primary Institution: University Of Nottingham, City Hospital, Nottingham NHS Trust

Does E-cadherin expression have prognostic value in breast cancer?

E-cadherin expression in human breast cancer appears to have minimal prognostic value, but may serve as a phenotypic marker.

66% of the breast cancers examined had reduced intensity of E-cadherin expression.
74% of the tumors had significant reductions in the proportion of E-cadherin-positive tumor cells.
Significant associations were found between E-cadherin expression and tumor type.
E-cadherin expression was not related to recurrence or distant metastases.

This study looked at a protein called E-cadherin in breast cancer and found that it doesn't really help predict how the cancer will behave.

The study analyzed E-cadherin expression in 174 breast tumors using immunohistochemistry.

E-cadherin expression was not related to several important clinical outcomes.

P = 0.026, P = 0.031

p ≤ 0.001

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