High Protein Formula Affects Piglet Gut Development
Author Information
Author(s): Chatelais Livie, Jamin Agnès, Gras-Le Guen Christèle, Lallès Jean-Paul, Le Huërou-Luron Isabelle, Boudry Gaëlle
Primary Institution: INRA, UMR 1079 SENAH, Saint-Gilles, France
Hypothesis
A high level of protein in infant formula will modulate intestinal microbiota and non-immune and immune intestinal barrier development.
Conclusion
A high protein level in formula affects the postnatal development of ileal microbiota, epithelial barrier, and immune function in piglets and alters ileal response to inflammatory mediators later in life.
Supporting Evidence
- HP piglets had a 35% higher protein intake than NP piglets.
- HP piglets showed increased daily weight gain compared to NP piglets.
- HP formula altered ileal permeability and immune cell density in piglets.
Takeaway
Feeding piglets a high protein formula helps them grow faster and changes how their gut works, which can affect their health later on.
Methodology
Piglets were fed either a normoprotein or a high protein formula from 2 to 28 days of age, and their growth, microbiota, and immune responses were measured.
Potential Biases
Potential bias in the selection of piglets and feeding protocols.
Limitations
The study was conducted on piglets, which may not fully represent human infants.
Participant Demographics
Crossbred piglets (Piétrain×(Large White×Landrace)) with low birth weight.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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