The Molecular Subtype Classification Is a Determinant of Sentinel Node Positivity in Early Breast Carcinoma

2011

Molecular Subtype Classification and Sentinel Node Positivity in Early Breast Cancer

Sample size: 2654 publication 10 minutes Evidence: high

Author Information

Author(s): Reyal Fabien, Rouzier Roman, Depont-Hazelzet Berenice, Bollet Marc A., Pierga Jean-Yves, Alran Severine, Salmon Remy J., Fourchotte Virginie, Vincent-Salomon Anne, Sastre-Garau Xavier, Antoine Martine, Uzan Serge, Sigal-Zafrani Brigitte, De Rycke Yann

Primary Institution: Institut Curie, Paris, France

Hypothesis

The study aims to decipher the interaction between molecular subtype classification and the probability of a positive sentinel node biopsy in early breast cancer patients.

Conclusion

The molecular subtype classification significantly interacts with the axillary and distant metastasis processes in breast cancer.

Supporting Evidence

The interaction between ER and HER2 status was a stronger predictor of positive sentinel node biopsy than ER status alone.
The multivariate model showed similar results in terms of discrimination and calibration across training and validation sets.
Patients with ER negative HER2 negative breast cancer had a lower rate of axillary metastasis.

Takeaway

This study found that the type of breast cancer can help predict whether cancer has spread to the lymph nodes, which is important for treatment decisions.