Influenza Virus Infection Affects the Glucocorticoid Receptor Response
Author Information
Author(s): Ge Xingyi, Rameix-Welti Marie-Anne, Gault Elyanne, Chase Geoffrey, dos Santos Afonso Emmanuel, Picard Didier, Schwemmle Martin, Naffakh Nadia
Primary Institution: Institut Pasteur, Paris, France
Hypothesis
Does influenza virus infection alter the function of the glucocorticoid receptor through the p23 cochaperone?
Conclusion
Influenza virus infection inhibits glucocorticoid receptor-mediated gene transactivation, potentially through a p23-independent pathway.
Supporting Evidence
- p23 relocalizes to the nucleus in influenza virus-infected cells.
- Viral infection impairs glucocorticoid receptor-mediated gene transactivation.
- p23 is not essential for viral multiplication in cultured cells.
- Influenza virus infection alters the glucocorticoid receptor's response to hormones.
Takeaway
When the flu virus infects cells, it can mess with how a hormone receptor works, which might make it harder for the body to respond to stress.
Methodology
The study used recombinant influenza viruses and various cell lines to analyze the interaction between the p23 cochaperone and the viral polymerase, as well as the effects on glucocorticoid receptor signaling.
Limitations
The study primarily focuses on cultured cells, which may not fully represent in vivo conditions.
Statistical Information
P-Value
p<0.02
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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