Oligo-Fucoidan's Role in Preventing Peritoneal Dialysis Fibrosis
Author Information
Author(s): Chen Yu-Wei, Wu Mei-Yi, Huang Nai-Jen, Wu Mai-Szu, Hsu Yung-Ho, Liao Chia-Te, Chen Cheng-Hsien, Pliego-Cortés Hugo, Bourgougnon Nathalie
Primary Institution: Taipei Medical University
Hypothesis
Can oligo-fucoidan mitigate peritoneal dialysis-associated fibrosis through its antioxidative and anti-inflammatory properties?
Conclusion
Oligo-fucoidan effectively prevents peritoneal thickening and fibrosis in a mouse model of peritoneal dialysis.
Supporting Evidence
- Oligo-fucoidan prevented high-glucose-induced apoptosis in human mesothelial cells.
- High-glucose dialysate caused significant peritoneal thickening in the mouse model.
- Oligo-fucoidan reduced the expression of pro-inflammatory cytokines in the serum of PD mice.
- Immunohistochemical staining showed less fibrosis in oligo-fucoidan treated groups.
- Oligo-fucoidan restored catalase expression in high-glucose treated cells.
- High glucose increased oxidative stress and inflammation in mesothelial cells.
Takeaway
Oligo-fucoidan, a substance from brown seaweed, helps protect the body from damage caused by a type of kidney treatment called peritoneal dialysis.
Methodology
The study used human mesothelial cells and a mouse model to investigate the effects of oligo-fucoidan on peritoneal fibrosis.
Limitations
The study did not account for the systemic effects of renal diseases on peritoneal fibrosis.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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