Impact of Retroperitoneal Margin on Survival in Pancreatic Cancer Surgery
Author Information
Author(s): Westgaard Arne, Tafjord Svetlana, Farstad Inger N, Cvancarova Milada, Eide Tor J, Mathisen Oystein, Clausen Ole Petter F, Gladhaug Ivar P
Primary Institution: Rikshospitalet University Hospital
Hypothesis
Does retroperitoneal margin involvement independently predict survival after pancreaticoduodenectomy?
Conclusion
Involvement of the retroperitoneal margin independently predicts survival after pancreaticoduodenectomy for adenocarcinoma.
Supporting Evidence
- Microscopic resection margin involvement was present in 40 tumours, with 32 involving the retroperitoneal margin.
- Pancreatic tumour origin was the only factor that independently predicted a poor prognosis in microscopically curative resections.
- Resection margin involvement was significantly associated with other poor histopathologic factors.
Takeaway
If cancer spreads to the back margin during surgery for pancreatic cancer, it can make it harder for patients to survive.
Methodology
114 consecutive macroscopically margin-free periampullary adenocarcinomas were examined using a standardized protocol for histopathologic evaluation.
Potential Biases
Potential underreporting of R1 resections due to non-standardized protocols.
Limitations
The study may not account for all variables influencing survival, and the retrospective nature of some evaluations could introduce bias.
Participant Demographics
55 women and 59 men; median age 68 years; range 41–82.
Statistical Information
P-Value
0.010
Confidence Interval
1.16–3.08
Statistical Significance
p = 0.010
Digital Object Identifier (DOI)
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