Comparative study of pulpal response following direct pulp capping using synthesized fluorapatite and hydroxyapatite nanoparticles
2025

Comparing Pulp Response to Different Capping Materials

Sample size: 72 publication 10 minutes Evidence: moderate

Author Information

Author(s): Eman M. Salem, Omnia M. Abdelfatah, Rania A. Hanafy, Rehab M. El-Sharkawy, Ghadir Elnawawy, Wafaa Yahia Alghonemy

Primary Institution: Pharos University in Alexandria

Hypothesis

This study aimed to investigate and compare the histological response of rabbit dental pulp after direct pulp capping with 3 different materials: mineral trioxide aggregate (MTA), nanoparticles of fluorapatite (Nano-FA), and nanoparticles of hydroxyapatite (Nano-HA).

Conclusion

MTA and Nano-HA are favorable materials for direct pulp capping, while Nano-FA produces nonpathological inflammatory cell reactions.

Supporting Evidence

  • Nano Hydroxyapatite showed better results than Nano Fluorapatite.
  • Nano Hydroxyapatite stimulates dentin bridge formation after 6 weeks.
  • Nano Fluorapatite causes nonpathological pulp inflammation.

Takeaway

The study tested three materials to see how well they help heal teeth after a procedure. Two of them worked better than the third.

Methodology

The study involved 72 rabbit teeth divided into three groups, each treated with a different capping material, and assessed after 4 and 6 weeks.

Potential Biases

The lack of a negative control group makes it challenging to determine if observed effects are due to the materials or natural healing processes.

Limitations

The use of rabbit teeth may limit applicability to humans, and the short follow-up period does not assess long-term effects.

Participant Demographics

Eighteen young male New Zealand white rabbits aged 4–5 months were used.

Statistical Information

P-Value

p<0.05

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1186/s12903-024-05285-4

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