Cytomegalovirus Infections in African-American Children
Author Information
Author(s): Wilms Isca R, Best Al M, Adler Stuart P
Primary Institution: Virginia Commonwealth University
Hypothesis
What are the ages and possible sources of cytomegalovirus infections among African-American children?
Conclusion
African-American children have lower CMV seroprevalence rates by age 20 compared to their adult mothers, with sibling-to-sibling transmission being a likely source of infection.
Supporting Evidence
- CMV seropositivity increased with age in children, reaching 11% at age 1.
- Adults had a CMV seropositivity rate of 84% at age 21.
- Sibling-to-sibling transmission was associated with CMV infections among children.
Takeaway
This study found that African-American kids get a virus called CMV less often than their parents, and they might catch it from their brothers and sisters.
Methodology
The study involved 157 African-American children and adolescents and their 113 household adults, using questionnaires and saliva samples for antibody testing.
Potential Biases
Potential selection bias due to recruitment from specific pediatric practices.
Limitations
The sample may not be representative of all African-Americans in Richmond, VA, as subjects were selected from those seeking medical consultation.
Participant Demographics
157 African-American children and adolescents aged 5 months to 20 years, and 113 household adults.
Statistical Information
P-Value
p<0.0001
Confidence Interval
95%CI = 4% – 24% for children at age 1; 95%CI = 69%–92% for adults at age 21
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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