Interphase cytogenetics of multicentric renal cell tumours confirm associations of specific aberrations with defined cytomorphologies
2000
Chromosomal Changes in Multicentric Renal Cell Tumours
Sample size: 239
publication
Author Information
Author(s): Amo-Takyi B K, Mittermayer C, Günther K, Handt S
Primary Institution: Institute of Pathology, Medical Faculty, Aachen University of Technology
Hypothesis
Are there specific chromosomal aberrations associated with different subtypes of renal cell tumours?
Conclusion
Papillary renal cell tumours tend to be multicentric and show specific chromosomal changes related to their growth.
Supporting Evidence
- 47% of the multicentric tumours were conventional RCCs and 53% papillary RCTs.
- Monosomy 3 was observed only in high-grade and/or advanced conventional RCCs.
- Trisomy 17 was detectable in papillary RCTs irrespective of tumour state.
Takeaway
This study looked at kidney tumors and found that some types have specific changes in their chromosomes that can help us understand them better.
Methodology
Chromosomal in situ hybridization was performed on 15 cases with 34 foci from nephrectomy specimens.
Digital Object Identifier (DOI)
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