A Dynamical Analysis of the Alignment Mechanism Between Two Interacting Cells
2025
Cell Alignment Mechanism Analysis
publication
Evidence: moderate
Author Information
Author(s): Leech Vivienne, Dalwadi Mohit P., Manhart Angelika
Primary Institution: Department of Mathematics, University College London, London, UK
Hypothesis
How do self-propelled cells align while avoiding overlap?
Conclusion
The interaction between self-propulsion and overlap avoidance is sufficient to generate alignment between two interacting cells.
Supporting Evidence
- Self-propulsion is necessary for perfect alignment but excessive self-propulsion hinders it.
- Cells initially move apart to avoid overlap before aligning.
- The analysis provides insights into the timescales involved in achieving alignment.
Takeaway
Cells that move and avoid overlapping can line up with each other, but if they push too hard, they might not align well.
Methodology
Analytical investigation of a dynamical system modeling two interacting self-propelled cells.
Limitations
The model does not capture collective effects and is limited to velocity alignment without considering nematic alignment.
Digital Object Identifier (DOI)
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