Growth of Human Pleural Mesothelioma in Rats and Mice
Author Information
Author(s): C.-J. Linden, L. Johansson
Primary Institution: University Hospital, Lund, Sweden
Hypothesis
The growth rate of a human pleural mesothelioma xenograft will differ between athymic rats and mice.
Conclusion
The study found that the human pleural mesothelioma grew faster in athymic rats than in mice, but the growth rate was similar at low tumor volumes.
Supporting Evidence
- The tumor take rate was 100% in both athymic rats and mice.
- The tumor volume doubling time decreased from 6 days to 3 days during serial passaging in rats.
- Only 1% of tumors in rats regressed, while none regressed in mice.
Takeaway
Scientists grew a type of lung cancer in special rats and mice to see how fast it would grow, and they found it grew faster in the rats.
Methodology
The tumor was xenografted into athymic rats and mice, and growth patterns were observed over multiple passages.
Limitations
The study did not assess the lowest cell number required for tumor take, which could have provided more precise evaluations.
Participant Demographics
The tumor was derived from a 66-year-old male patient with pleural mesothelioma.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
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