Beneficial and Detrimental Effects of Plasmin(ogen) during Infection and Sepsis in Mice
2011
The Role of Plasminogen in Infection and Sepsis in Mice
Sample size: 10
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Guo Yongzhi Li, Jinan Hagström, Elin Ny Tor, Chakravortty Dipshikha
Primary Institution: Umeå University
Hypothesis
What are the functional roles of active plasmin in infection and sepsis?
Conclusion
Plasmin is beneficial in infection but promotes inflammation in sepsis, leading to tissue damage and increased mortality.
Supporting Evidence
- Wild-type mice had higher survival rates than plasminogen-deficient mice during infection.
- In sepsis, plasminogen-deficient mice showed the highest survival rates.
- Cytokine levels were significantly lower in plasminogen-deficient mice during sepsis.
Takeaway
Plasmin helps mice fight infections but can make them sicker during sepsis, which is when the body has a severe response to infection.
Methodology
The study used gene-deficient mice to investigate the roles of plasmin during infection and sepsis induced by Staphylococcus aureus.
Limitations
The study was conducted in mice, which may not fully represent human responses.
Participant Demographics
Male mice aged 8-12 weeks.
Statistical Information
P-Value
0.04
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website