Study of Angiopteris helferiana as an Anticancer Agent
Author Information
Author(s): Pandey Bipindra, Thapa Shankar, Biradar Mahalakshmi Suresha, Singh Bhoopendra, Ghale Jaya Bahadur, Kharel Pramod, Jha Prabhat Kumar, Yadav Ram Kishor, Dawadi Sujan, V. Poojashree
Primary Institution: Department of Pharmacy, Madan Bhandari Academy of Health Sciences, Hetauda, Nepal
Hypothesis
The study aims to evaluate the phytochemical profiling and bioactivity of Angiopteris helferiana against HepG2 cell lines.
Conclusion
The study suggests that bioactive compounds from Angiopteris helferiana could be developed as promising anticancer agents, although further in-vivo studies are required.
Supporting Evidence
- Seventeen phytoconstituents were identified in A. helferiana extract.
- Quercetin showed significant binding energy of -8.8 kcal/mol against the human PPAR-δ receptor.
- The extract exhibited moderate cytotoxic activity with an IC50 value of 236.93 μg/mL.
Takeaway
Researchers looked at a plant called Angiopteris helferiana to see if it can help fight liver cancer. They found some good stuff in it that might help, but they need to do more tests.
Methodology
The study used LC-MS for profiling phytoconstituents and MTT assay to evaluate cytotoxic activity on HepG2 cell lines.
Limitations
The study does not claim precision in LC-MS data interpretation due to lack of accurate reference mass data and limited research on A. helferiana.
Digital Object Identifier (DOI)
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