Conservation of Human Protein Interactions in Other Organisms
Author Information
Author(s): Kevin R. Brown, Igor Jurisica
Primary Institution: University of Toronto
Hypothesis
Higher degree proteins in human protein-protein interaction networks are expected to be preferentially conserved when mapped to lower eukaryotes.
Conclusion
Human proteins show a correlation between the number of interacting partners and evolutionary conservation, with protein complexes being preferentially conserved.
Supporting Evidence
- Human proteins with more interacting partners are more conserved across species.
- Protein complexes are preferentially conserved compared to transient interactions.
- Transferring human protein interactions to yeast enhances the understanding of protein networks.
Takeaway
This study shows that proteins in humans that interact with many other proteins are more likely to be conserved when looking at other organisms like yeast.
Methodology
The study involved mapping human protein interactions to lower eukaryotes and analyzing the conservation of these interactions.
Potential Biases
Potential bias due to the reliance on high-throughput data which may not capture all interactions accurately.
Limitations
The study may be limited by the evolutionary distance between species and the quality of the interaction data.
Participant Demographics
The study focused on human proteins and their interactions with proteins from model organisms like yeast, mouse, and rat.
Statistical Information
P-Value
3.9 × 10-4
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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