Valproate and Its Effects on WFS1 in Bipolar Disorder
Author Information
Author(s): Kakiuchi Chihiro, Ishigaki Shinsuke, Oslowski Christine M., Fonseca Sonya G., Kato Tadafumi, Urano Fumihiko
Primary Institution: University of Massachusetts Medical School
Hypothesis
The therapeutic effect of valproate in bipolar disorder may be mediated by changes in expression of neuroprotective genes.
Conclusion
Valproate induces expression of WFS1 and enhances its dissociation from GRP94 in neurons, suggesting a mechanism for its therapeutic effects in bipolar disorder.
Supporting Evidence
- Valproate increases WFS1 protein expression levels in Neuro-2a cells.
- Valproate enhances the dissociation of WFS1 from GRP94.
- WFS1 is an important component for mitigating ER stress.
Takeaway
Valproate helps treat bipolar disorder by increasing a protein called WFS1, which helps cells deal with stress.
Methodology
The study involved treating neuronal cell lines with valproate and measuring WFS1 expression and its interaction with GRP94.
Digital Object Identifier (DOI)
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