Impact of Aortic Calcification on Mortality in Older Patients
Author Information
Author(s): Horbal Steven, Leis Aleda, Holcombe Sven, Karvonen-Gutierrez Carrie
Primary Institution: University of Michigan
Hypothesis
How do age and sex modify the relationship between aortic calcification and mortality in older patients?
Conclusion
The study found that the impact of aortic calcification on mortality risk varies by age and sex, particularly showing a protective effect in older females.
Supporting Evidence
- 18.3% of the sample were 80+ years old.
- The mortality rate in the sample was 38.0%.
- Those with elevated aortic calcification had a 99% higher mortality hazard.
- A significant interaction was observed between age category, sex, and aortic calcification status.
- Elevated aortic calcification was associated with a 35% lower mortality hazard in females age 80+.
Takeaway
This study looked at older patients and found that having a lot of calcium in aorta can mean different things for men and women, especially as they get older.
Methodology
Cox regression was used to assess the relationship between aortic calcification and mortality, adjusted for body mass index and Charlson Comorbidity Index.
Limitations
The study only included patients without cardiovascular disease and may not generalize to all older adults.
Participant Demographics
Patients were aged 65 years and older, with 18.3% being 80+ years.
Statistical Information
Confidence Interval
95% CI 1.66, 2.41
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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