Acute Pancreatitis from Colchicine Use
Author Information
Author(s): Ting Joseph Yuk Sang
Primary Institution: Department of Emergency Medicine, Mater Adult Hospital
Hypothesis
Can colchicine, even at therapeutic doses, cause acute pancreatitis in patients with renal impairment?
Conclusion
Colchicine may be associated with acute pancreatitis even with therapeutic dosing, particularly in elderly patients with renal impairment.
Supporting Evidence
- Colchicine is known to have a narrow therapeutic window.
- Acute pancreatitis has rarely been reported with colchicine, typically in overdose cases.
- The patient had pre-existing renal impairment, which may have contributed to the adverse effect.
Takeaway
A 79-year-old man got pancreatitis after taking colchicine for gout, showing that this medicine can cause problems even when used correctly, especially in older people with kidney issues.
Methodology
Case report of a single patient with acute pancreatitis after starting colchicine.
Potential Biases
Potential for bias due to the nature of a single case report.
Limitations
Findings are based on a single case report, limiting generalizability.
Participant Demographics
79-year-old male with multiple comorbidities including renal impairment.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website