Modeling Doxorubicin Delivery with Glucosamine Carrier
Author Information
Author(s): Pirawattana Thongjun, Srinophakun Thongchai
Primary Institution: Kasetsart University
Hypothesis
Can doxorubicin be effectively released from glucosamine(ethylene glycol) oligomers under different pH conditions?
Conclusion
Doxorubicin can be released from glucosamine(ethylene glycol) oligomers in acidic and neutral conditions, but not in basic conditions.
Supporting Evidence
- Doxorubicin can be released into acidic and neutral solutions but not into basic solutions.
- Increasing the length of ethylene glycol chains enhances drug release under acidic conditions.
- Micelle formation is facilitated by the presence of glucosamine(ethylene glycol) and doxorubicin.
Takeaway
This study shows how a special carrier can help deliver cancer medicine to the right place in the body, especially in acidic environments like the stomach.
Methodology
The study simulated the encapsulation and release of doxorubicin from glucosamine(ethylene glycol) oligomers using molecular modeling techniques.
Limitations
The study primarily focuses on simulations and may not fully represent in vivo conditions.
Digital Object Identifier (DOI)
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