Microbial Characteristics of Bile in Gallstone Patients
Author Information
Author(s): Zheng Xin, Yan Yunjun, Li Xin, Liu Mimin, Zhao Xiaoyue, He Jing, Zhuang Xuewei
Primary Institution: Shandong Provincial Third Hospital, Shandong University
Hypothesis
Investigate the differences in microbial communities cultured from bile specimens of patients with gallstones.
Conclusion
The study found significant differences in microbial diversity and detection rates among gallstone patients, with specific microbes associated with recurrence.
Supporting Evidence
- 76 microbes were cultured from 5,153 patients.
- E. coli, K. pneumoniae, and E. faecalis were the most frequently identified microbes.
- Microbial diversity was significantly lower in the recurrence group compared to the non-recurrence group.
Takeaway
This study looked at the germs in the bile of people with gallstones and found that certain germs can help predict if someone will have gallstones again.
Methodology
Clinical data and bile microbial status were collected from 9,939 gallstone patients, and statistical analysis was performed to assess relationships between microbes and clinical features.
Potential Biases
Potential biases due to missing data and reliance on self-reported recurrence.
Limitations
Missing data for gallstone size and comorbidities; recurrence rates could not be accurately calculated due to follow-up difficulties.
Participant Demographics
Majority were females (53.30%) aged 60-74 years.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI, 0.95–0.99
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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