How HSV Infection Triggers Immune Responses
Author Information
Author(s): Gonzalez-Dosal Regina, Horan Kristy A., Rahbek Stine H., Ichijo Hidenori, Chen Zhijian J., Mieyal John J., Hartmann Rune, Paludan Søren R.
Primary Institution: Department of Biomedicine, Aarhus University, Aarhus, Denmark
Hypothesis
HSV infection induces production of reactive oxygen species (ROS) that enhance signaling from pattern recognition receptors.
Conclusion
The study shows that ROS are essential for activating innate immune responses against HSV infection.
Supporting Evidence
- HSV infection leads to early production of ROS.
- ROS are required for the activation of NF-κB and IRF-3 pathways.
- All known receptors for HSV require cellular redox levels for successful signaling.
- S-glutathionylation of TRAF3 and TRAF6 is important for ROS-dependent activation.
- Antioxidants inhibit the cytokine response following HSV infection.
Takeaway
When the herpes virus infects cells, it makes them produce tiny particles called ROS that help the immune system fight off the virus.
Methodology
The study used live microscopy and various biochemical assays to analyze ROS production and its effects on immune signaling pathways.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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