Comparing Two Types of Zhizhu Pills for Treating Functional Dyspepsia
Author Information
Author(s): Wu Hongli, Jing Zhiwei, Tang Xudong, Wang Xinyue, Zhang Shengsheng, Yu Yanan, Wang Zhong, Cao Hongxin, Huang Luqi, Yu Youhua, Wang Yongyan
Primary Institution: China Academy of Chinese Medical Sciences
Hypothesis
The study aims to compare the efficacy of two kinds of Zhizhu pills in treating functional dyspepsia of spleen-deficiency and qi-stagnation syndrome.
Conclusion
Zhizhu pills containing immature orange fruit of Citrus aurantium L. were found to be more effective than those containing Citrus sinensis Osbeck in treating functional dyspepsia.
Supporting Evidence
- The cure-markedly effective rates were 67% for the IFCA group and 45% for the IFCS group.
- No adverse events were observed in either group during the trial.
- The trial was stopped early after the third interim analysis indicated significant results.
Takeaway
This study tested two types of herbal pills to see which one helps people with stomach problems feel better, and one type worked better than the other.
Methodology
A randomized, group sequential, double-blinded, multicenter trial was conducted with patients taking one of the two Zhizhu pills for 4 weeks.
Limitations
The study did not include a placebo group and used criteria that were modified after the trial ended.
Participant Demographics
Participants were aged 18 to 65 years, with a mix of genders and no significant differences in baseline characteristics.
Statistical Information
P-Value
0.0036
Confidence Interval
95%CI: 1.40 to 6.06
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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