Ethanol Extract of Schisandra Fruit Reduces Liver Fat in Mice
Author Information
Author(s): Si-Yuan Pan, Yu Zhi-Ling, Dong Hang, Xiang Chun-Jing, Fong Wang-Fun, Ko Kam-Ming
Primary Institution: Beijing University of Chinese Medicine
Hypothesis
Does the ethanol extract of Fructus Schisandrae decrease hepatic triglyceride levels in hypercholesterolemic mice?
Conclusion
The ethanol extract of Fructus Schisandrae significantly decreases hepatic triglyceride levels in hypercholesterolemic mice.
Supporting Evidence
- The ethanol extract treatment decreased hepatic triglyceride levels by up to 35%.
- Fenofibrate treatment reduced hepatic triglyceride levels by 61%.
- Acute toxicity tests showed that the ethanol extract was relatively non-toxic.
Takeaway
This study found that a special fruit extract can help reduce fat in the liver of mice that eat a fatty diet.
Methodology
Mice were fed a high-fat diet and treated with the ethanol extract of Fructus Schisandrae or fenofibrate, and their serum and liver lipid levels were measured.
Limitations
The study was conducted on mice, and results may not directly translate to humans.
Participant Demographics
Male ICR mice, weighing 18-20g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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