Gene Expression and Survival in Osteosarcoma
Author Information
Author(s): Dalla-Torre Cristiane A, Yoshimoto Maisa, Lee Chung-Hae, Joshua Anthony M, de Toledo Silvia RC, Petrilli Antônio S, Andrade Joyce AD, Chilton-MacNeill Susan, Zielenska Maria, Squire Jeremy A
Primary Institution: Instituto de Oncologia Pediátrica (IOP-GRAACC), Universidade Federal de São Paulo
Hypothesis
The expression levels of THBS3, SPARC, and SPP1 are associated with the biological behavior and survival of osteosarcoma patients.
Conclusion
Three genes were identified with differential expression patterns that are associated with metastasis and invasion in osteosarcoma.
Supporting Evidence
- THBS3 was expressed at significantly high levels in biopsies from patients with metastasis at diagnosis.
- High SPARC expression correlated with worse event-free survival.
- SPP1 overexpression was associated with better overall survival.
Takeaway
This study looked at how certain genes affect the growth and spread of a type of bone cancer called osteosarcoma, finding that some genes can help predict how well patients will do.
Methodology
The study used cDNA arrays to screen for gene expression in osteosarcoma samples and validated findings with real-time PCR.
Participant Demographics
Patients were younger than 25 years with high-grade osteosarcoma.
Statistical Information
P-Value
p = 0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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