Diagnosing Ovarian Cancer with Immunoscintigraphy
Author Information
Author(s): Magnani P, Fazio F, Grana C, Songini C, Frigerio L, Pecorelli S, Mangili G, Colombo N, Mariani C D A, Paganelli G
Primary Institution: INB-CNR, Institute H. S. Raffaele, University of Milan, Milan, Italy
Hypothesis
Can three-step immunoscintigraphy provide a high accuracy non-invasive diagnostic procedure for recurrent ovarian carcinoma?
Conclusion
Three-step immunoscintigraphy shows high diagnostic accuracy for detecting recurrent ovarian carcinoma.
Supporting Evidence
- Twenty-one patients studied were true-positive.
- Five were true-negative.
- Four were false-positive.
- None was false-negative.
- The diagnostic accuracy was 87%.
- The positive predictive value was 84%.
- The negative predictive value was 100%.
Takeaway
Doctors tested a new way to find out if ovarian cancer came back without doing surgery, and it worked really well for most patients.
Methodology
Thirty patients were injected with specific antibodies and imaged for tumor recurrences, followed by surgical re-exploration.
Limitations
The study's findings need confirmation in a larger group of patients.
Participant Demographics
Thirty patients with suspected recurrent ovarian carcinoma.
Digital Object Identifier (DOI)
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