New Approach for Cardiovascular Diseases Using Single Chain Fragment Variable
Author Information
Author(s): Zahid Rukhshan, Wang Juncheng, Cai Zecheng, Ishtiaq Ayesha, Liu Meng, Ma Dan, Liang Yan, Xu Yuekang
Primary Institution: Anhui Normal University
Hypothesis
Can single-chain fragment variable (scFv) molecules improve the diagnosis and treatment of cardiovascular diseases (CVDs)?
Conclusion
The review highlights the potential of scFv molecules as effective theranostic agents for cardiovascular diseases, addressing both diagnostic and therapeutic needs.
Supporting Evidence
- scFvs can be engineered for enhanced affinity and specificity.
- scFvs have applications in both diagnostics and therapeutics for CVDs.
- Recent studies show scFvs can effectively target atherosclerotic plaques.
Takeaway
Scientists are exploring tiny proteins called scFvs that can help find and treat heart problems better than current medicines.
Methodology
The review summarizes recent advancements in scFv engineering and their applications in targeting cardiovascular disease-related antigens.
Limitations
Challenges include issues with specificity, stability, immunogenicity, and scalability of scFv molecules.
Digital Object Identifier (DOI)
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