MULTIMODEL APPROACHES IDENTIFY CONSERVED ROLE OF TRP CATABOLIC PATHWAY IN THE REGULATION OF LIFE- AND HEALTHSPAN
2024
Role of Tryptophan Pathway in Aging
publication
Author Information
Author(s): Oz Naci, Kaya Alaattin
Primary Institution: Virginia Commonwealth University
Hypothesis
The Kynurenine pathway plays a conserved role in regulating life- and healthspan.
Conclusion
Decreased tryptophan catabolism may help modulate lifespan and healthspan.
Supporting Evidence
- The KYN pathway is linked to aging and neurodegenerative disorders.
- Increased activity of IDO1 and IDO2 is associated with inflammaging.
- Kynurenines may serve as biomarkers of frailty in humans.
Takeaway
This study looks at how a specific pathway in our body that breaks down tryptophan can affect how long we live and how healthy we are as we age.
Methodology
Developed knockout transgenic mouse strains lacking IDO1, IDO2, or both, and used multi-omics approaches to analyze biological age and metabolic changes.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website