Effects of Salivary Gland Removal on Tumor Development in Mice
Author Information
Author(s): W.W.-K. King, J.E. De Vries, R.U. Boelhouwer, W.D.A. Ford, A.N. Kingsnorth, J.S. Ross, R.A. Malt
Primary Institution: Shriners Burns Institute and Massachusetts General Hospital, and the Department of Surgery, Harvard Medical School
Hypothesis
Does submandibular sialadenectomy affect the incidence of duodenal tumors induced by N-methyl-N'-nitro-N-nitrosoguanidine in mice?
Conclusion
Submandibular sialadenectomy does not significantly affect the incidence of duodenal tumors in mice treated with MNNG.
Supporting Evidence
- Male sialadenectomized mice weighed 10% less than sham-operated mice.
- The incidence of tumors in male sialadenectomized mice was 31.8%, compared to 17.6% in male sham-operated mice.
- All tumors were located within 8cm distal to the pylorus and were carcinomas.
Takeaway
When scientists removed a salivary gland from mice, it didn't change how many tumors they got from a certain chemical.
Methodology
Mice underwent submandibular sialadenectomy or sham surgery, then received MNNG in drinking water for 32 weeks, followed by autopsy to check for tumors.
Limitations
The sample size may have been too small to detect significant differences in tumor incidence.
Participant Demographics
CD-1 male and female mice, aged six weeks.
Statistical Information
P-Value
0.05
Statistical Significance
p>0.05
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