Antifungal Activity of Solventlessly Synthesized Organomercurials
2002
Antifungal Activity of Solventless Synthesized Organomercurials
publication
Evidence: moderate
Author Information
Author(s): M. Kidwai, R. Venkataramanan, B. Dave
Primary Institution: Department of Chemistry, University of Delhi
Hypothesis
The study investigates the antifungal activity of new organomercurial derivatives synthesized using a solventless method.
Conclusion
The synthesized organomercurials exhibited significant antifungal activity against A. niger and A. flavous.
Supporting Evidence
- All organomercurial compounds displayed significant antifungal activity against both A. niger and A. flavous.
- Thiocompounds with phenyl substituents showed better activity compared to other derivatives.
- Methyl substituents on the aryl mercury side chain also demonstrated good antifungal activity.
Takeaway
Scientists made new compounds that can fight fungi without using harmful solvents, and they found that these compounds work really well.
Methodology
The compounds were synthesized using microwave irradiation and tested for antifungal activity using the paper disc diffusion method.
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