A randomised controlled trial investigating the effect of n-3 long-chain polyunsaturated fatty acid supplementation on cognitive and retinal function in cognitively healthy older people: the Older People And n-3 Long-chain polyunsaturated fatty acids (OPAL) study protocol
2006

Effect of n-3 Fatty Acids on Cognitive and Retinal Function in Older Adults

Sample size: 798 publication Evidence: moderate

Author Information

Author(s): Alan D. Dangour, Felicity Clemens, Diana Elbourne, Nicky Fasey, Astrid E. Fletcher, Pollyanna Hardy, Graham E. Holder, Felicia A. Huppert, Rosemary Knight, Louise Letley, Marcus Richards, Ann Truesdale, Madge Vickers, Ricardo Uauy

Primary Institution: London School of Hygiene & Tropical Medicine

Hypothesis

An increased dietary intake of n-3 long-chain polyunsaturated fatty acids will have a positive effect on cognitive performance in older people in the UK.

Conclusion

The study aims to determine if n-3 fatty acids can slow cognitive decline and improve retinal function in older adults.

Supporting Evidence

  • Older people in the UK often consume diets low in fish.
  • Previous studies suggest that higher fish consumption is linked to reduced risk of cognitive impairment.
  • n-3 LCPs are crucial for brain development and function.

Takeaway

This study is trying to find out if eating more fish can help older people think better and see better.

Methodology

A double-blind randomised placebo-controlled trial among adults aged 70–79 years, comparing n-3 LCP supplementation with a placebo.

Potential Biases

Potential bias in participant selection and self-reported dietary intake.

Limitations

The study may have limitations related to participant dropout and the generalizability of findings to all older adults.

Participant Demographics

Healthy, cognitively normal adults aged 70–79 years.

Digital Object Identifier (DOI)

10.1186/1475-2891-5-20

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