Transcription Factors in Breast Cancer
Author Information
Author(s): Soini Ylermi, Tuhkanen Hanna, Sironen Reijo, Virtanen Ismo, Kataja Vesa, Auvinen Päivi, Mannermaa Arto, Kosma Veli-Matti
Primary Institution: University of Eastern Finland
Hypothesis
Are the transcription factors zeb1, twist, and snai1 important in the spread of breast tumor cells?
Conclusion
The study found that zeb1 and twist are mainly expressed in the stromal compartment of breast carcinomas, with twist expression in epithelial cells linked to poorer patient outcomes.
Supporting Evidence
- Nuclear expression of twist was found in 3.6% of epithelial tumor cells.
- 75% of stromal cells showed nuclear expression of zeb1.
- Twist expression in epithelial cells was associated with poorer patient outcomes.
Takeaway
This study looked at how certain proteins in breast cancer cells might help them spread. It found that one protein, twist, can be linked to worse outcomes for patients.
Methodology
Immunohistochemistry was used to analyze the expression of zeb1, twist, and snai1 in tumor and stromal compartments of breast carcinomas.
Limitations
The study did not find significant associations between stromal expression of zeb1 and twist with tumor size or metastasis.
Participant Demographics
The study included 388 cases of invasive and in situ breast carcinomas.
Statistical Information
P-Value
p = 0.054
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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