Study of Apple Allergen Mal d 1 Genes and Their Impact on Allergy
Author Information
Author(s): Gao Zhongshan, Weg Eric W van de, Matos Catarina I, Arens Paul, Bolhaar Suzanne THP, Knulst Andre C, Li Yinghui, Hoffmann-Sommergruber Karin, Gilissen Luud JWJ
Primary Institution: Zhejiang University
Hypothesis
The study investigates the allelic diversity of Mal d 1 genes in apple cultivars and their association with allergenicity.
Conclusion
The protein variants of Mal d 1.04 and -1.06A are associated with differences in allergenicity among apple cultivars.
Supporting Evidence
- Mal d 1.01 and Mal d 1.02 were highly conserved across cultivars.
- Mal d 1.04 and Mal d 1.06A showed significant variability in protein variants.
- The study confirmed associations between specific Mal d 1 alleles and allergenicity in multiple cultivars.
Takeaway
Some apples can make people allergic, and this study found that certain genes in apples are linked to how allergic they can make someone.
Methodology
The study assessed allelic diversity by sequencing Mal d 1 genes in apple cultivars and compared these with skin prick test responses.
Potential Biases
Potential bias in patient selection for skin prick tests could affect allergenicity results.
Limitations
The study focused only on a limited number of apple cultivars and may not represent all genetic variations.
Participant Demographics
Participants were birch pollen sensitized patients with oral allergy symptoms after eating apples.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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