Anti-Cancer Effects of Xanthones from Pericarps of Mangosteen
2008
Anti-Cancer Effects of Xanthones from Mangosteen
publication
Evidence: moderate
Author Information
Author(s): Akao Yukihiro, Nakagawa Yoshihito, Iinuma Munekazu, Nozawa Yoshihori
Primary Institution: Gifu International Institute of Biotechnology
Hypothesis
Can xanthones from mangosteen pericarps exhibit anti-cancer effects?
Conclusion
Xanthones, particularly α-mangostin, show significant anti-cancer effects through mechanisms like apoptosis and cell cycle arrest.
Supporting Evidence
- α-Mangostin induced apoptosis in human colon cancer cells.
- Xanthones showed growth inhibitory effects on cancer cells.
- Combined treatment of α-mangostin and 5-FU enhanced anti-cancer effects.
- α-Mangostin has been shown to enhance NK cell activity in mice.
Takeaway
Xanthones from mangosteen can help fight cancer by making cancer cells stop growing and die.
Methodology
The study involved examining the effects of xanthones on human colon cancer cells and assessing their mechanisms of action.
Statistical Information
P-Value
p<0.05 for 0.02% α-mangostin, p<0.01 for 0.05% α-mangostin
Statistical Significance
p<0.05
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