Prion Protein Accumulation in the Skin of Hamsters and Sheep
Author Information
Author(s): Thomzig Achim, Schulz-Schaeffer Walter, Wrede Arne, Wemheuer Wilhelm, Brenig Bertram, Kratzel Christine, Lemmer Karin, Beekes Michael
Primary Institution: Robert Koch-Institut, Berlin, Germany
Hypothesis
Do prions target the skin and accumulate there during infection?
Conclusion
The study found that pathological prion protein accumulates in the skin of hamsters and sheep infected with scrapie.
Supporting Evidence
- PrPSc was detected in skin samples from hamsters before the onset of symptoms.
- PrPSc accumulation was found in the skin of sheep naturally infected with scrapie.
- Skin samples showed PrPSc localization primarily in nerve fibers.
Takeaway
This study shows that prions can build up in the skin of infected animals, which might help spread the disease.
Methodology
Hamsters were orally infected with scrapie and skin samples were analyzed for prion protein accumulation at various time points.
Limitations
The study had a small sample size and focused on specific body regions.
Participant Demographics
Hamsters and sheep, specifically those infected with scrapie.
Digital Object Identifier (DOI)
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