Proliferating mesodermal cells in murine embryos exhibiting macrophage and lymphendothelial characteristics
2008
Dual Origin of Lymphatic Endothelial Cells in Mouse Embryos
publication
Evidence: moderate
Author Information
Author(s): Buttler Kerstin, Ezaki Taichi, Wilting Jörg
Primary Institution: University Medicine Goettingen
Hypothesis
Are lymphatic endothelial cells in murine embryos derived from both embryonic veins and mesenchymal lymphangioblasts?
Conclusion
The study suggests that lymphatic endothelial cells in mice originate from both specific embryonic veins and mesenchymal lymphangioblasts.
Supporting Evidence
- Cells co-expressing lymphendothelial and macrophage markers were found in the mesoderm of murine embryos.
- Proliferation studies indicated high rates of cell division in lymphatic endothelial cells.
- Markers Prox1, Lyve-1, and F4/80 were used to identify lymphatic endothelial characteristics.
Takeaway
This study found that some cells in mouse embryos can turn into lymphatic cells and that they come from two different places in the body.
Methodology
The study used immunohistochemistry and double/triple staining techniques to analyze embryonic mouse tissues.
Digital Object Identifier (DOI)
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