Functional Cure of SIVagm Infection in Rhesus Macaques
Author Information
Author(s): Pandrea Ivona, Gaufin Thaidra, Gautam Rajeev, Kristoff Jan, Mandell Daniel, Montefiori David, Keele Brandon F., Ribeiro Ruy M., Veazey Ronald S., Apetrei Cristian
Primary Institution: Tulane National Primate Research Center
Hypothesis
Understanding the mechanisms of infection control in elite controllers may shed light on the correlates of control of disease progression in HIV infection.
Conclusion
The study demonstrates that SIVagm infection in rhesus macaques can be completely controlled, leading to immune restoration, and this control can be reverted by depleting CD8+ T cells.
Supporting Evidence
- SIVagm infection was elite-controlled in rhesus macaques, allowing for a model of elite controlled HIV infection.
- Complete recovery of CD4+ T cells was observed after four years of viral control.
- Viral control was independent of MHC types and not due to a limited ability of the virus to replicate.
Takeaway
Researchers found that a type of monkey can fight off a virus without medicine, and if they remove certain immune cells, the virus comes back.
Methodology
Rhesus macaques were infected with SIVagm and monitored for viral load and immune response over time, with some undergoing CD8+ cell depletion.
Limitations
The study is limited to an animal model and may not fully translate to human HIV infection.
Participant Demographics
Twelve male rhesus macaques aged 5–11 years.
Statistical Information
P-Value
0.03
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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