Estimating Vaccine-Derived Poliovirus Infection Spread
Author Information
Author(s): Alison Wringe, Paul E. M. Fine, Roland W. Sutter, Olen M. Kew
Primary Institution: London School of Hygiene and Tropical Medicine
Hypothesis
What is the extent of vaccine-derived poliovirus (VDPV) infection spread in various outbreaks?
Conclusion
The study estimates that hundreds of thousands to several million individuals were likely infected during documented cVDPV outbreaks.
Supporting Evidence
- Eight outbreaks of cVDPV have been documented, with 114 confirmed cases.
- Estimates suggest that several million individuals may have been infected during these outbreaks.
- The study highlights the importance of understanding VDPV spread for future vaccination strategies.
Takeaway
This study looks at how many people might have caught a virus from a vaccine that was supposed to help them. It found that a lot more people got sick than we thought.
Methodology
The study analyzed epidemiological and virological parameters to infer the number of individuals infected during cVDPV outbreaks.
Potential Biases
Potential biases in case ascertainment and reporting may affect the accuracy of infection estimates.
Limitations
The study relies on estimates and may not capture all infections due to underreporting and incomplete surveillance.
Participant Demographics
The study includes data from multiple countries with varying vaccination coverage and population immunity levels.
Digital Object Identifier (DOI)
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