Genetic Factors Affecting Bone Density in Older Men
Author Information
Author(s): Laura M Yerges, Lambertus Klei, Jane A Cauley, Kathryn Roeder, Candace M Kammerer, Kristine E Ensrud, Cara S Nestlerode, Cora Lewis, Thomas F Lang, Elizabeth Barrett-Connor, Susan P Moffett, Andrew R Hoffman, Robert E Ferrell, Eric S Orwoll, Joseph M Zmuda
Primary Institution: University of Pittsburgh
Hypothesis
There are genetic variants associated with trabecular and cortical volumetric bone mineral density at the femoral neck.
Conclusion
The study identified several novel genetic variants associated with cortical and trabecular volumetric bone mineral density in older men.
Supporting Evidence
- Seven SNPs in five genes were consistently associated with cortical vBMD.
- Twelve SNPs in nine genes were consistently associated with trabecular vBMD.
- None of the SNPs associated with one bone compartment were associated with the other.
Takeaway
Scientists found that certain genes can affect how strong bones are in older men, which helps understand osteoporosis better.
Methodology
The study used a two-stage genotyping design with older Caucasian men from the Osteoporotic Fractures in Men Study, analyzing genetic variants associated with bone mineral density.
Potential Biases
Potential bias due to the exclusion of participants taking bone-altering medications and the focus on a specific demographic.
Limitations
The study focused only on older Caucasian men, which may limit the generalizability of the findings to other populations.
Participant Demographics
Caucasian men aged 65 years or older.
Statistical Information
P-Value
4 × 10−4
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website