TRAIL inhibits angiogenesis stimulated by VEGF expression in human glioblastoma cells
2006
TRAIL inhibits blood vessel formation in glioblastoma cells
publication
Evidence: high
Author Information
Author(s): Cantarella G, Risuglia N, Dell'eva R, Lempereur L, Albini A, Pennisi G, Scoto G M, Noonan D N, Bernardini R
Primary Institution: University of Catania
Hypothesis
Can TRAIL influence angiogenesis-related genes in human glioblastoma cells?
Conclusion
TRAIL effectively inhibits factors that contribute to the aggressiveness of glioblastoma, suggesting it could be a target for new therapies.
Supporting Evidence
- TRAIL reduced VEGF mRNA and protein levels in glioblastoma cells.
- TRAIL inhibited new blood vessel formation in both in vitro and in vivo models.
- TRAIL decreased the expression of MMP-2, TIMP-2, and SPARC in glioblastoma cells.
Takeaway
TRAIL is like a superhero that stops bad cells in brain tumors from making new blood vessels, which helps the tumor grow.
Methodology
The study used human glioblastoma cell lines and HUVECs to assess the effects of TRAIL on gene expression and blood vessel formation.
Statistical Information
P-Value
p<0.0089
Statistical Significance
p<0.0089
Digital Object Identifier (DOI)
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