VEGF-D and Ovarian Cancer Prognosis
Author Information
Author(s): Yokoyama Y, Charnock-Jones D S, Licence D, Yanaihara A, Hastings J M, Holland C M, Emoto M, Umemoto M, Sakamoto T, Sato S, Mizunuma H, Smith S K
Primary Institution: University of Cambridge
Hypothesis
The presence of VEGF-C and VEGF-D is correlated with patient survival and lymphatic metastasis in ovarian carcinoma.
Conclusion
VEGF-D is an independent prognostic factor for poor survival in ovarian carcinoma patients.
Supporting Evidence
- Patients with high levels of VEGF-D had a significantly worse prognosis.
- VEGF-D was found to be an independent prognostic factor for poor survival.
- VEGF-C and VEGF-D levels increased with the progression from benign tumors to carcinomas.
Takeaway
This study found that a protein called VEGF-D can help predict how well patients with ovarian cancer will do, with higher levels meaning a worse outlook.
Methodology
Immunohistochemical examination of 90 ovarian tumors to assess the presence of VEGF-C, VEGF-D, and VEGFR-3.
Potential Biases
Potential bias in patient selection and retrospective data collection.
Limitations
The study is retrospective and may not account for all confounding factors.
Participant Demographics
Women surgically treated for ovarian tumors at Hirosaki University Hospital between 1989 and 2000.
Statistical Information
P-Value
p<0.0001 for VEGF-D and lymph node metastasis.
Confidence Interval
95% CI: 2.33–83.33 for VEGF-D.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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