Magnesium and Potassium Loss After Cisplatin Treatment
Author Information
Author(s): Lajer H, Bundgaard H, Secher N H, Hansen H H, Kjeldsen K, Daugaard G
Primary Institution: Rigshospitalet, University of Copenhagen
Hypothesis
Does cisplatin treatment lead to significant intracellular magnesium and potassium depletion in patients?
Conclusion
Cisplatin treatment caused significant magnesium and potassium depletion in most patients, often without corresponding changes in plasma levels.
Supporting Evidence
- P-Mg levels fell significantly after treatment, indicating magnesium depletion.
- Skeletal muscle magnesium content decreased significantly post-treatment.
- The fraction of patients low in both plasma and skeletal muscle magnesium increased after treatment.
Takeaway
When patients get treated with a medicine called cisplatin, they can lose important minerals like magnesium and potassium, which can make them feel weak and tired.
Methodology
The study involved muscle biopsies and blood samples from patients receiving cisplatin-based chemotherapy to measure magnesium and potassium levels.
Potential Biases
Potential bias due to exclusion of patients with diabetes or thyroid/parathyroid diseases.
Limitations
Some patients could not provide both pre- and post-treatment biopsies, and the study excluded patients with certain health conditions.
Participant Demographics
The study included 68 patients, with a mean age of 54 years, and a male to female ratio of 46:19.
Statistical Information
P-Value
p<0.01
Confidence Interval
95% CI
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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